New hormone discovery boosts bone strength

Unveiling the power of maternal brain hormone

Recent research led by the University of California, San Francisco (UCSF) has uncovered a groundbreaking hormone in female mice, known as the maternal brain hormone (MBH), which significantly enhances bone density and strength. This discovery could have profound implications for understanding bone health across different ages and genders.

Impact of MBH on bone health

MBH, a protein called CCN3, is secreted by neurons in the brain's arcuate nucleus and plays a crucial role in bone remodeling and fracture repair. This hormone surges during lactation when estrogen levels drop, helping to maintain bone strength despite significant calcium depletion to nourish newborns.

Research findings and future potential

Experiments have shown that increasing MBH levels in mice leads to remarkable increases in bone mass and strength. This is especially vital for older female mice with low estrogen levels, where MBH treatment more than doubled their bone mass. The potential for MBH to benefit humans, particularly in conditions of low bone density, is an exciting prospect for future healthcare.

Broader implications for bone health

The hormone's effects are not limited to female mice. MBH has been shown to enhance bone strength in males and females of all ages, suggesting its utility could be widespread. Understanding its mechanisms can lead to innovative treatments for osteoporosis and other bone-related conditions.

Conclusion

The discovery of MBH opens new doors for the treatment of bone density issues across the lifespan. As research progresses, this could lead to breakthroughs in how we treat and manage bone health in various populations, potentially increasing both lifespan and healthspan.